First, a summary: Aseptic production process, the most commonly used globe valve is a diaphragm valve, usually referred to as the diaphragm valve. The reason why the diaphragm valve in the aseptic production process, first, because of its simple structure, and second, its low price, which makes it so far almost no "competitors." The only valve that can compete with a diaphragm valve is the so-called bellows globe valve, the so-called bellows valve. Such bellows shut-off valves, because of their high cost, are still difficult to contend with diaphragm valves despite having better technical advantages than diaphragm valves. In this paper, through the comparison of diaphragm valve and bellows valve, the advantages and disadvantages of the two valves are more clear. Second, compared with the diaphragm valve, Vesta bellows advantages of the valve: In the sterile field of industrial areas "bellows valve and diaphragm valve competition" a long time. For a long time, the diaphragm valve with its simple structure, low cost and convenient cleaning and disinfection and occupy an advantage. Compared with the diaphragm valve, bellows valve in the market variety of specifications too little. Today, however, Vesta bellows valve from uchenhagen fills this void. (A), Vesta bellows superior performance in the following areas: 1, emptying performance (1), when the need for the use of the diaphragm in the horizontal pipe valve, valve manufacturer must ensure that the angle in accordance with the provisions of the installation in the horizontal pipe Diaphragm valves, otherwise in the process equipment operation, the diaphragm valve will encounter some problems of emptying, can not be completely discharged body of the medium. However, different types of diaphragm valves, diaphragm valves manufactured by different manufacturers, different nominal flow rate of the diaphragm valve installation angle is different, and often to the design and manufacture of aseptic flow of process equipment has brought great trouble. In the T-type diaphragm valve, the problem of this empty body is more obvious. Vesta bellows valves do not suffer from this problem when compared to diaphragm valves. No matter what the body structure of the Vesta bellows valve, there is no "dead corner" during the no-load operation of the process equipment to ensure tightness To cut off the pipe. Moreover, it can be installed in a variety of installation methods in aseptic process piping systems. 2. In the medical manufacturing industry, the aseptic process equipment consists of many horizontal pipes and vertical pipes. In the design of the pharmaceutical equipment, the bellow valve must be installed and used in a specific place due to the pipe position and technical reasons. For example, if a diaphragm valve is installed in a vertical pipe, it must be connected by a 90 ° elbow in the same horizontal plane. The T-type structure of the diaphragm valve production costs and high, compared with the diaphragm structure of different valve body shape, the bellows valve in size and shape, with the pipe connection and installation more advantages. As the two types of globe valve structure of different types, therefore, in the initial design of aseptic flow process equipment, should choose the various parts should choose which type of globe valve. 3, in the field of medicine, food and biotechnology output equipment has a large number of need to disinfect the valve. Large valves, such as the Stericom series, have little if any of these sterilization needs. Because, in these process equipment, the amount of media required to transport less and less, with less flow, almost indiscriminate selection of the diaphragm valve. The new bellows valve has a smaller volume, with different pipe diameter with, in this regard more advantages than the diaphragm valve. 2, the core components Vesta bellows valve key components is TFM1705 PTFE cut-off bellows, in addition to its resistance to corrosion of a variety of chemical media, TFM1705 material also meets FDA Code of Federal Regulations §177.1550 on "perfluoro Carbide resin "requirements. Its smooth surface (Ra ≤ 0.8mm), reliable sealing, large switching distance and other characteristics of these characteristics, for the best CIP / SIP disinfection and cleaning are very beneficial. For more than three years, this patented bellows valve has succeeded in gaining a foothold in the market and is able to strictly isolate the inside of the pipe from the atmospheric environment outside the pipe in aseptic pipe. 3, the comparison of equipment utilization As a user of the equipment, the equipment in the entire equipment life cycle as much as possible to use the production equipment, that is to say: the utilization of equipment should be as high as possible. The equipment maintenance means that the equipment must stop production, but also put some equipment maintenance costs. Bellows valves are generally worn; in the diaphragm valve, valve wear, after a certain period of time must be replaced diaphragm, diaphragm life depends on the length of the corresponding production process. On the one hand, the process equipment flow medium corrosion, pipe cleaning and disinfection temperature, process equipment working pressure and flow and other operating parameters will affect the life of the diaphragm; the other hand, the diaphragm-type valve on and off diaphragm deformation It is also an important factor that determines the diaphragm's service life. Most of the diaphragm valve damage is not due to the use of the production process, on the contrary, is due to mechanical compression damage. Although diaphragm diaphragms have different degrees of resilience, different coatings, and different PTFE shields, there is external invisible wear to all diaphragm valves (surface erosion and particle adhesion caused by internal media) . Therefore, in order to avoid the production of aseptic process being forced to stop due to the damage of the diaphragm valve, in practice, it is common practice to change the diaphragm before the specified service life. As a result, both the number of diaphragms forced to be replaced, resulting in maintenance costs, or equipment downtime is significantly more than PTFE bellows valve, the bellows valve performance is good and durable, longer service life. Another advantage of the Vesta bellows shut-off valve with pneumatic drive is that it can be used for almost any process production.